| 祛痰新药氨溴索的合成方法研究 |
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| 引用本文： | 雷光清,刘晓珍,穆报春. 祛痰新药氨溴索的合成方法研究[J]. 中国药物化学杂志, 2000, 10(3): 205-206 |
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| 作者姓名： | 雷光清 刘晓珍 穆报春 |
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| 作者单位： | 中国人民解放军药物化学研究所,北京 |
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| 摘 要： | 以邻氨基苯甲酸甲酯为起始原料,经溴化、肼解、碱性条件下分解成醛并同时亚胺基化,最后还原等五步反应,得到目标化合物氨溴索,总收率为３５．７％。实验结果表明：该路线具有原料价廉易得,反应条件温和,产物易纯化,收率高等优点,适合工业化生产。
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| 关 键 词： | 氨溴索 溴己新 合成 祛痰药 新药 |
The Research in the Synthetic Method of New Expectorant Ambroxol |
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| LeiGuangqing,Liu Xiaozhen,Mu Baochun,He Xiaowei. The Research in the Synthetic Method of New Expectorant Ambroxol[J]. Chinese Journal of Medicinal Chemistry, 2000, 10(3): 205-206 |
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| Authors: | zze" >LeiGuangqing,Liu Xiaozhen,Mu Baochun,He Xiaowei |
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| Affiliation: | LeiGuangqing,Liu Xiaozhen,Mu Baochun,He Xiaowei(Institute of Pharmaceutical Chemistry of PLA,Beijing 102205) |
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| Abstract: | Ambroxol was synthesised by the total yield of 35.7% from metheyl o aminokenzonate via five steps of bromination,hydrazinolysis,aldehyde formation and imination and reduction.The result showed that it was a cheap,moderate and simple technical method. |
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| Keywords: | ambroxol bromhexine synthesis |
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