核黄素对高血压患者有关病理因素的影响

观察核黄素 ( RBF)对 65例高血压病 ( EH)患者有关病理因素的影响。结果显示 :1EH患者血小板聚集性 ( PAG)、血清丙二醛 ( MDA)和血脂水平 ( PL)显著高于正常组 ,血清超氧化物歧化酶 ( SOD)活性明显低于正常组 ;2服药后 RBF组 PAG显著受到抑制 ,MDA含量和 PL明显下降 ,SOD活性升高 ,而对照组的上述各项指标则无明显的改变。表明 RBF对 EH患者有关的病理因素具有显著的抑制作用 ,可望成为预防 EH心血管并发症的一种有效药物。

Effects of Riboflavin on Pathologic Factors Relative to Hypertension

Aim Effects of Riboflavin(RBF) on pathologic factors relatied to hypertension were studied in patients with essential hypertension(EH). Method 65 untreated patients with EH were randomly divided into RBF group (B, n=35) and control group (C,n=30). In addition to anti-hypertension treatment for all patients , RBF (75mg·d+{-1})was added to administration in B group for 30days. Platelet aggregation(PAG) in blood was examined and serum malondiadehyde(MDA) content and superoxide dismutase (SOD) activity and plasma lipid level (PL) were measured before and after treatment as compared to the indices of healthy control subjects (N, n=30). Results Serum MDA content and PL and PAG were much higher while SOD activity was lower in both B and C groups than that in N group . After treatment PAG indices-Pt mas, PtH and PtK were inhibited (P<0.05,P<0.01,and P<0.01,respectively) and serum MDA content and PL were decreased significantly(P<0.01 and P<0.05, respectively while SOD activity was increased (P<0.05) in B group, but the indices had no changes in C group. Conclusion RBF can inhibit effects of pathologic factors and become a preventive medicine for cardiovascular complication in patients with EH.