Lymphoid tissue collagen deposition in HIV-infected patients correlates with the imbalance between matrix metalloproteinases and their inhibitors |
| |
Authors: | Diaz Alba García Felipe Mozos Anna Caballero Miguel León Agathe Martinez Antonio Gil Cristina Plana Montserrat Gallart Teresa Gatell Jose M Alós Llúcia |
| |
Institution: | Department of Pathology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain. |
| |
Abstract: | We studied the lymphoid tissue biopsies of 20 patients with chronic human immunodeficiency virus (HIV) infection by analyzing collagen deposition, CD4+ cell number, and gene expression of metalloproteinases (MMPs; MMP-2, MMP-9) and tissue inhibitors of MMPs (TIMPs; TIMP-1, TIMP-2). HIV-infected patients had significantly increased collagen deposition (P = .001), fewer CD4+ T cells (P = .05), and decreased MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios (P = .01), compared with HIV-negative control patients. Moreover, we found a significant negative correlation between collagen deposition and the MMP-9/TIMP-1 ratio (ρ = -0.50; P = .047). To our knowledge, this is the first time that MMP/TIMP imbalance has been correlated with lymphoid tissue collagen deposition and incomplete immune recovery in HIV-infected patients, even after long-term antiretroviral treatment. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|