腔内近距离放疗结合体外放疗及同步化疗治疗中央型肺癌

目的 探讨腔内近距离放疗配合体外放疗和同步化疗治疗中央型肺癌的疗效.方法 42例中央型肺癌患者随机分为治疗组和对照组.采用腔内近距离放疗配合体外放疗和同步化疗治疗累及气管、支气管的中央型肺癌21例.结果 治疗组和对照组总有效率分别为85.7%和57.1%,差异有统计学意义(P＜0.05).主要不良反应为刺激性剧烈咳嗽和骨髓抑制.结论 腔内近距离放疗中央型肺癌能迅速改善由气道阻塞引起的临床症状,与体外放疗和同步化疗联合应用能达到较好的治疗效果.

Clinical observation of intraluminal brachytherapy combined with external radiation and synchronous chemotherapy in the treatment of bronchial lung cancer

Objective To evaluate the acute side effects and efficacy of the intraluminal brachytherapy combined with external radiation and synchronous chemotherapy in the treatment of bronchial lung cancer.Methods From June 2001 to June 2003,42 patients with bronchial lung cancer were divided into treatment group and control group randomly.21 lung cancer patients with major airway obstruction were treated by combined intralumihal brachytherapy with external beam radiotherapy and synchronous chemotherapy.Results The overall response rate(CR+PR)in treatment group and control group were 85.7% and 57.1%(P＜0.05).There were no serious complication during the treatment except for irritant cough and leukocytopenia.Conclusion Intraluminal brachytherapy may result in symptom improvement in patients with major airway occlusion of lung cancer.The intraluminal bmchytherapy combined with external beam radiothempy and synchronous chemotherapy is an effective method in treatment of lung cancer.