Plasma protein binding of ritodrine at parturition and in nonpregnant women |
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Authors: | A S Gross K F Brown |
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Institution: | (1) Department of Pharmacy, University of Sydney, Sydney, Australia;(2) Foetal Pharmacology Laboratory, Foundation 41, Surry Hills, Australia |
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Abstract: | Summary The binding of ritodrine HCl in whole plasma from healthy nonpregnant women, parturients and matched umbilical venous plasma and in solutions of HSA and 1-AGP has been studied by equilibrium dialysis. Binding to plasma from nonpregnant subjects and HSA was independent of ritodrine concentration over a wide range.The free fraction in plasma was high and significantly different between groups of nonpregnant ( =0.64), parturient ( =0.68) and matched umbilical venous plasma ( =0.75). It would seem that variability in transplacental transfer of ritodrine, as a result of plasma binding fluctuations, will be minor. |
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Keywords: | plasma protein binding ritodrine hydrochloride albumin binding alpha1-acid glycoprotein parturition |
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