Antilithic effects of extracts from <Emphasis Type="Italic">Urtica dentata</Emphasis> hand on calcium oxalate urinary stones in rats |
| |
Authors: | Ming?Xiang Shasha?Zhang Jingli?Lu Lulu?Li Wenrui?Hou Mingxing?Xie Email author" target="_blank">Ying?ZengEmail author |
| |
Institution: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resources Evaluation, School of Pharmacy, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030, China 2. Department of Ultrasonography 3. Department of Pharmaceutics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
| |
Abstract: | This study examined the potential antilithic effects of a traditional Chinese medicine Urtica dentata Hand (UDH) in experimental rats and screened the optimal extract of UDH as a possible therapeutic agent for kidney stones.
The rat model of urinary calcium oxalate stones was induced by intragastric (i.g.) administration of 2 mL of 1.25% ethylene
glycol (EG) and 1% ammonium chloride (AC) for 28 days and was confirmed by Color Doppler ultrasound imaging. The rats in different
experimental groups were then intragastrically given petroleum ether extract (PEE), N-butanol extract (NBE), aqueous extract
(AqE) of UDH, Jieshitong (positive control drug), and saline, respectively. Treatment with NBE significantly reduced the elevated levels of urinary
calcium, uric acid, phosphate, as well as increased urinary output. Accordingly, the increased calcium, oxalate levels and
the number of calcium oxalate crystals deposits were remarkably reverted in the renal tissue of NBE-treated rats. In addition,
NBE also prevented the impairment of renal function to decrease the contents of blood urea nitrogen (BUN) and creatinine.
Taken together, these data suggest that NBE of UDH has a beneficial effect on calcium oxalate urinary stones in rats by flushing
the stones out and protecting renal function. |
| |
Keywords: | hyperoxaluria calcium oxalate urinary stones extracts Urtica dentata Hand ethylene glycol ammonium chloride |
本文献已被 CNKI 维普 万方数据 PubMed SpringerLink 等数据库收录! |
|