富铬酵母降低糖尿病大鼠血糖的生物效应评价

目的 :　研究富铬酵母对四氧嘧啶致实验性糖尿病大鼠的降血糖作用。方法 :　对糖尿病大鼠连续口服富铬酵母〔 Cr 2 0 0μg/ (kg bw· d)〕和〔 Cr 2 0μg/ (kg bw· d)〕以及普通酵母〔 Cr 1μg/ (kg bw· d)〕4w,观察记录每天的饮水和进食情况。每周末采集尾静脉血 ,测定血糖、总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白 (LDL)、高密度脂蛋白 (HDL )、胰岛素、C肽的含量。结果 :　各治疗组大鼠的体重明显高于糖尿病组 ,各治疗组大鼠的血糖水平、TG、TC、LDL、胰岛素及 C肽显著降低 ,而 HDL升高。高剂量富铬酵母的降血糖作用明显高于其他各组。结论 :　富铬酵母在体内可以改善糖和脂代谢 ,可用来预防和治疗糖尿病。

EVALUATION OF GLUCOSE-LOWERING EFFECT OF CHROMIUM-RICH BREWERS YEAST ON DIABETIC RATS

Objective: The glucose lowering effect of Cr rich yeast on the experimental diabetic rats was studied. Methods: The fasting diabetic rats were orally administered with Cr rich yeast 200 μg and 20 μg Cr/(kg bw·d)) and the normal yeast 1 μg Cr/(kg bw·d) for 4 weeks continuously. The diet consumption and body weight were recorded daily. Blood was collected from the tail vein once a week and the levels of glucose, insulin, C peptide, TG, TC, HDL, and LDL in serum were measured. Results: The body weight of rats in various treated groups were significantly higher than that of diabetic group. The levels of serum glucose, TG, TC, LDL, insulin and C peptide were significantly decreased. Moreover, the content of HDL was obviously increased. The glucose lowering effect of the high dose of Cr rich yeast was more significant than that of the others. Conclusion: The beneficial effect of Cr rich yeast on glucose and lipid metabolism was observed in diabetic rats. It suggests that Cr rich yeast can be used in both prevention and treatment of diabetes.