| 兔蛛网膜下腔出血后外周血中TNF的变化及其意义探讨 |
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| 引用本文： | 邓志锋,张铭文,蒋先惠,薜德麟.兔蛛网膜下腔出血后外周血中TNF的变化及其意义探讨[J].江西医学院学报,1997(3). |
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| 作者姓名： | 邓志锋 张铭文 蒋先惠 薜德麟 |
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| 作者单位： | 江西医学院第二附属医院神经外科，同济医科大学同济医院神经外科 |
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| 摘 要： | 为探讨继发于蛛网膜下腔出血后的迟发性脑血管痉挛的发病机制，采用兔枕大池二次注血法复制蛛网膜下腔出血模型，用经颅多普勒监测脑基底动脉血管痉挛的发生情况，实验前、后分别检测外周血中ＴＮＦ含量。结果显示实验组动物迟发性脑血管痉挛的发生率达８４．６２％，实验第７ｄ外周血中ＴＮＦ含量较实验前升高（Ｐ＜０．０１）。结果表明：在蛛网膜下腔出血后脑血管痉挛的形成中确有免疫因素的参与。
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| 关 键 词： | 蛛网膜下腔出血 脑缺血.暂时性 肿瘤坏死因子 动物.实验 兔 |
Changes in TNF of the Peripheral Blood and its Significance Following Subarachnoid Hemorrhage in the Rabbits |
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| Deng Zhifeng,Zhang Mingwen.Changes in TNF of the Peripheral Blood and its Significance Following Subarachnoid Hemorrhage in the Rabbits[J].Acta Academiae Medicinae Jiangxi,1997(3). |
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| Authors: | Deng Zhifeng Zhang Mingwen |
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| Abstract: | The purpose of this study was to investigate the etiopathology of delayed cerebral vasospasm following subarachnoid hemorrhage(SAH).In this study two injections of autologous blood were made into the cisternal magna of the rabbit to produce models of SAH.The transcranial doppler ultrasound was used to monitor the occurence of cerebrovasospasm.The tumor necrosis factor (TNF) in the blood was examined before and after the experiment.The results obtained showed the level of TNF was higher after experiment than that before ( P <0 01),and the morbidity of delayed cerebral vasospasm was 84.62% in the experimental group.This study indicates that the delayed cerebral vasospasm following SAH is elicited via an immunoreaction. |
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| Keywords: | subarachnoid hemorrhage cerebral ischemia transient tumor necrosis factor animals laboratory rabbits |
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