使君子酸钾对人体蛔虫驱除效力的初步报告

使君子对人体具有驱除蛔虫的效力,已属定论.作者陈、李曾从使君子内提炼得一结晶性物质,命名为使君子酸钾;经药理初步试验,证明对蚯蚓显示毒效,具有驱虫效力。为了进一步证实此物质对人体蛔虫是否确具驱除效力起见,作者在1949年进行了临床试用.本试验在一女童教养所进行.学生204人,均在同一环境条件生活及成长。粪便经虫卵常规检查,发现均有蛔虫寄生.为了便于比较驱虫效力,一部分患者采用了山道年进行治疗.为了说明使君子酸钾的驱虫效力,以及它是否为使君子中的有效成分,采

A PRELIMINARY STUDY OF ANTHELMINTIC ACTION OF POTASSIUM QUISQUALATE

Potassium quisqualate has been isolated in crystalline form from the seeds of Quisqualis chinensis (Shih Chun Tze), a popular ascaracide in China. This salt has been proved to be highly toxic to earthworm. In order to investigate whether this salt possesses anthelmintic action, a clinical study of potassium quisqualate as well as raw or baked quisqualis seeds in comparison with santonin was made on 204 pa- tients with proved ascariasis. They were divided into 5 groups: One group received various dosages of 0.025, 0.050, 0.075, 0.100 and 0.125 gm of potassium quisqualate. The next three groups were given the seeds, raw or baked at 50°and 100℃, the amount of which varied with the ages of the patients. Those under twelve receiv- ed 5 gms, while those above twelve 10 gms of seeds. The last group received 0.120 gm of santonin. All were given without any laxatives. Each dose was given 2 hours after supper and before breakfast in the following morning. The number of ascarids in the stools was counted and recorded daily, and any observable side effects were also recorded. The results of this study indicate: (1) Potassium quisqualate possesses a definite anthehmintic action in patients. It may be considered as an anthelmintic principle of Quisqualis chinensis. (2) Without any laxatives, a dosage of 0.125 gm of potassium quisqualate produces highly anthelmintic action. The percentage of patients who excreted ascarids approaches nearly to that of those received santonin, and is greater than that of those received the raw or baked seeds. (3) The only drawback of using Quisqualis chinensis and potassium quisqualate is their side effect of causing hiccough. The side effect of the potassium salt is less marked than that of the raw seeds. The undesirable effect of the raw seeds decreases to some extent during the baking process.