SLE患者皮质类固醇治疗前后血清IL－2和TNF－α水平的比较

ＳＬＥ患者皮质类固醇治疗前后血清ＩＬ－２和ＴＮＦ－α水平的比较刘国英①瞿国伟②ＳＬＥ是一种以免疫调节异常为特征的自身免疫性疾病，而免疫调节主要是通过多种细胞因子相互作用实现的。因此，研究ＳＬＥ病人细胞因子变化将有助于阐明该病的发病机理，我们检测了１４...

Detection of PGL-1 antigen and S100 protein in the histopathologic diagnosis of leprosy

Immunohistopathologic staining technique using monoclonal antibody against PGL-1 antigen and anti-S100 protein antibody were applied along with the routine histopathologic HE and AF staining techniques on 9 confirmed patients with paucibacillary(PB) and 1 confirmed multibacillary(MB) leprosy as well as on 1 suspected case of PB and 11 MB clinically suspected relapsed cases of leprosy.In the 9 confirmed PB patients,3 were AF,7 PGL-1 and 6 S100 protein staining positive;but in the suspected PB relapsed case,though AF and PGL-I staining were negative,but S100 protein staining was positive in the infiltrated areas of the biopsy. In the confirmed MB cases all the specific criteria were positive.whereas in the 11 suspected MB relapsed cases only 8 showed AF and PGL-1 staning positive.6 showed S100 protein staining positive.In the 3 AF and PGL-1 staining negative cases,relapse can not be confirmed.Thus PGL-1 and S100 protein staining are of assistance in the diagnosis of early leprosy and in the verification of relapse from reversal reaction in problem cases.