血管紧张素转换酶抑制剂对主动脉狭窄性高血压...

Effect of angiotensin converting enzyme inhibitor on arterial wall thickening in coarctation hypertension

In order to clarify the role of renin-angiotensin systems on arterial wall thickening in hypertension, the effect of angiotensin converting enzyme inhibitor, captopril, in rats with aortic coarctation was studied. Captopril was given by intragastric instillation, 3 mg/kg B, W. twice a day, since the 2nd day after the operation, and the animals were examined 4 to 6 weeks later. Blood pressures from carotid and femoral arteries were recorded directly; the heart and standardized segments of the aorta were weighted; aorta, coronary and renal arterioles were studied morphometrically; renin activity, angiotensin II and aldosterone concentrations were assayed. The results showed that captopril reduced significantly thickening of the aortic and arteriolar wall in both the hypertensive forequarters and the normotensive hindquarters. This suggests that renin-angiotensin system plays a role in the development of arterial wall thickening in hypertension.