| 体外循环中温度对小儿神经系统的影响 |
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| 引用本文： | 朱德明,王伟,黄继红,黄惠民,张蔚,傅惟定.体外循环中温度对小儿神经系统的影响[J].中国体外循环杂志,2008,6(4):201-203. |
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| 作者姓名： | 朱德明 王伟 黄继红 黄惠民 张蔚 傅惟定 |
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| 作者单位： | 上海交通大学医学院附属上海儿童医学中心心胸外科,上海,200127 |
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| 摘 要： | 目的本研究探讨常温体外循环和浅低温体外循环对小儿脑代谢的影响。方法室间隔缺损病例随机分为两组，分别在常温（35℃以上）和浅低温（32℃）下手术纠治。在ECC前、ECC结束和术后20h检测S100蛋白浓度。用近红外线光普法（MRS）测量脑组织氧合血红蛋白（HbO2）、脱氧血色蛋白（HbD）及氧化型细胞色素aa3（CytOx）。结果两组S100蛋白都在转流结束时明显升高，术后回落，两组比较无显著差异（P〉0．05）。转流前期可见浅低温组HbO2高于常温组，升温后浅低温组HbO2显著下降，低于常温组（P〈0．05）。浅低温组CytOx在整个转流过程中低于常温组（P〈0．05）。结论常温转流对于简单心脏病手术是安全的，不会造成神经系统明显损害。
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| 关 键 词： | 体外循环 小儿 温度 神经系统 |
The Effects of Temperature on Neurological System during Pediatric Extracorporeal Circulation |
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| ZHU De-ming,WANG Wei,HUANG Ji-hong,HUNAG Hui-min,ZHNAG Wei,FU Wei-ding.The Effects of Temperature on Neurological System during Pediatric Extracorporeal Circulation[J].Chinese Journal of Extracorporeal Circulation,2008,6(4):201-203. |
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| Authors: | ZHU De-ming WANG Wei HUANG Ji-hong HUNAG Hui-min ZHNAG Wei FU Wei-ding |
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| Institution: | ZHU De-ming,WANG Wei,HUANG Ji-hong,HUNAG Hui-min,ZHNAG Wei,FU Wei-ding(Department of Pediatric Thoracic , Cardiovascular Surgery,Shanghai Children\'s Medical Center,Shanghai Jiao Tong University Medical School,Shanghai 200127,China) |
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| Abstract: | OBJECTIVE To evaluate the effects of normothermic and mild hypothermic extracorporeal circulation(ECC) on pediatric neurological system.METHODS Patients with ventricular septum defect were randomly divided into two groups,normothermic group and mild hypothermic group.S100 protein was detected before ECC,at the termination of ECC,and post-operative 20 hours.Oxyhemoglobin(HbO2),deoxygenated hemoglobin(HbD),and CytOx were measured with near-infrared spectroscopy(NIRS).RESULTS The changes of S100 protein in two... |
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| Keywords: | Extracorporeal circulation Pediatric Temperature Neurological system |
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