| 2-巯基-N-氧化吡啶钠的抗肿瘤及抑制免疫作用 |
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| 引用本文： | 王宗锐,冯仕苏,唐慰萍,邓卫华,黄书伟.2-巯基-N-氧化吡啶钠的抗肿瘤及抑制免疫作用[J].中国药理学通报,1992(2). |
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| 作者姓名： | 王宗锐 冯仕苏 唐慰萍 邓卫华 黄书伟 |
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| 作者单位： | 湛江医学院药理教研室，湛江医学院药理教研室，湛江医学院病理教研室，湛江医学院病理教研室，湛江医学院电镜室 广东524023，广东524023 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 2—巯基—N—氧化吡啶钠(巯氧吡啶钠Sodium Pyridineth-ione,SPT)在试管内0.01mg/L可抑制多种传代人癌细胞株;抑制细胞有丝分裂和损害细胞膜相结构;对动物移植性肿瘤无效,但明显增强氟脲嘧啶对小鼠S_(180)的抑瘤作用。使胸腺和脾脏重量明显减轻,抑制SRBC诱导小鼠血清溶血素反应,抑制DNCB诱导豚鼠皮肤迟发型超敏反应,抑制PHA诱导大鼠淋巴细胞转化。
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| 关 键 词： | 巯氧吡啶钠 抗肿瘤作用 免疫抑制 有丝分裂指数 |
STUDIES ON ANTITUMOR AND IMMUNOSUPPRESSION EFFECTS OF SODIUMPYRIDINETHIONE |
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| Wang Zhongrui,Feng Shisu,Tang Weiping.STUDIES ON ANTITUMOR AND IMMUNOSUPPRESSION EFFECTS OF SODIUMPYRIDINETHIONE[J].Chinese Pharmacological Bulletin,1992(2). |
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| Authors: | Wang Zhongrui Feng Shisu Tang Weiping |
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| Abstract: | Sodium pyridinethione, in vitro, possesses a significant inhibitory effect on human tumor cell strains, such as Hela, CNE-2 and Raji cell strain. In vivo, it has not inhibitory effect on the transplanted tumors, such as S180, LLC and EC, but significantly enhance the inhibitory effects of 5-Fu on S180.
Sodium pyridinethione markedly decreases the weight of spleen and thymus, and serum hemolysins reaction induced by SRBC in mice and skin delayed type hypersensitivity reaction induced by DNCB in guinea pigs It also inhibits lyphocyte transformation induced by PHA. All these effects are shown clear dose-response relationship. Our experiments showed that sodium pyridinethion is a new antitumor and immuno-inhibitory compound. |
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| Keywords: | Sodium pyridinethione Antitumor Immunosuppres-sion Mitotic index |
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