吡喹酮合并阿苯达唑治疗华支睾吸虫病的效果观察

采用吡喹酮１８０ｍｇ／ｋｇ、阿苯达唑９０ｍｇ／ｋｇ及吡喹酮９０ｍｇ／ｋｇ合并阿苯达唑４５ｍｇ／ｋｇ，３ｄ分服，每日３次，分别治疗华支睾吸虫病患者６６例、６２例和７４例，治后１个月粪检虫卵阴转率依次为９８．５％（６５／６６），６１．３％（３８／６２）和８７．８％（６５／７４）；未转阴者的虫卵减少率分别为９９．７％，６５．０％和９７．３％。吡喹酮合并阿苯达唑治疗组的疗效虽稍逊于吡喹酮治疗组，但其对轻、中度感染者的疗效仍较满意，且药物副反应少而轻，对合并感染钩虫、蛔虫和鞭虫等肠道线虫的患者亦有很好的疗效。

EFFICACY OF PRAZIQUANTEL COMBINED WITH ALBENDAZOLE IN THE TREATMENT OF CLONORCHIASIS

This paper reported on the clinical efficacy of praziquantel albendazole combination in the treatment of clonorchiasis in Guangxi.Two hundred and two cases were divided into three groups.The first group comprised 66 cases who were treated with praziquantel at 180 mg/kg bwt for three days.The second group consisted of 62 cases who were treated with albendazole at 90 mg/kg bwt for three days.In the third group,74 cases were treated with 90 mg/kg bwt praziquantel plus 45 mg/kg albendazole for three days.The results showed that the negative conversion rates were 98.5%,61.3% and 87.8% in groups one,two and three,respectively,one month after treatment.In some cases who continued to be egg positive,the reduction rates in faecal egg counts were 99.7%,65.0% and 97.3%,respectively.Although the cure rate in group three was not as high as in group one,the side effects were more mild and transient and the cost of treatment could be reduced by 60% as compared with group one.In cases with light and moderate infections,the praziquantel albendazole combination proved more effective.In addition,the praziquantel albendazole combination was also highly effective for treating those cases who were infected with Ascaris,Trichuris or hookworm.