IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity |
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| Authors: | Sosa Lucas Dupraz Sebastian Laurino Lisandro Bollati Flavia Bisbal Mariano Cáceres Alfredo Pfenninger Karl H Quiroga Santiago |
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| Affiliation: | Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba y Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Consejo de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina. |
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| Abstract: | How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors. |
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