1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat–fed mice |
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| Institution: | 1. Department of Food and Nutrition, Korea University, Seoul 136-704, Republic of Korea;2. Department of Applied Bioscience, CHA University, Gyeonggi-do 463-400, Republic of Korea;3. Department of Public Health Sciences, Graduate School, Korea University, Seoul 136-703, Republic of Korea;4. Department of Food Science and Nutrition, Dong-A University, Busan, Republic of Korea;5. R&D Center for Natural Science, Biotopia Co., Ltd., Chuncheon 200-883, Republic of Korea;6. Korea University Guro Hospital, Korea University, Seoul 152-703, Republic of Korea;1. Department of Pharmacology and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.;2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan.;3. School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.;4. Department of Parasitology, Chung Shan Medical University, Taichung, Taiwan.;5. Department of BioIndustry Technology, Da-Yeh University, Dacun, Changhua, Taiwan.;6. Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan. |
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| Abstract: | The aim of this study was to determine whether 1-deoxynojirimycin (DNJ) isolated from Bacillus subtilis MORI beneficially influences lipid metabolism and mitochondrial function in the liver of mice fed a high-fat diet in addition to the anti-obesity properties of DNJ. Male C57BL/6 mice (n = 29; 5 weeks old) were randomly assigned to three groups: normal control diet (CTL, n = 10), high-fat diet (HF, n = 10), and high-fat diet supplemented with DNJ (DNJ, n = 9). After 12 weeks, the HF group exhibited higher overall weight gain, of the liver, and of various fat pads than the CTL and DNJ groups did. The HF group also showed greater expression of C/EBPα and CD36 mRNA in the liver than that in the CTL and/or DNJ groups. In addition, mRNA expressions of AAC and FAS were lower, while mRNA expression of PGC-1β was higher in the liver of the DNJ group than that of the HF group. The hepatic expression of p-AMPK/AMPK was higher in the DNJ group than in the HF group. This study provides novel insight into the protective effect of DNJ supplementation against obesity-induced hepatic lipid abnormalities and mitochondrial dysfunction. |
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