丙戊酸镁防治偏头痛的疗效观察

目的:探讨丙戊酸镁治疗偏头痛的有效性及安全性。方法:81例偏头痛患者,其中因失访脱落6例,按照就诊顺序编号,奇数者为氟桂利嗪组(37例,给予氟桂利嗪治疗),偶数者为丙戊酸镁组(38例,给予丙戊酸镁缓释片治疗)。观察2组患者治疗前及治疗3个月后的头痛发作频率及头痛严重程度。结果:治疗后氟桂利嗪组和丙戊酸镁组头痛发作频率均较治疗前明显降低(P<0.01),但2组差异无统计学意义(P>0.05);治疗后氟桂利嗪组和丙戊酸镁组头痛严重程度评分均较治疗前显著降低(P<0.01),且2组差异有统计学意义(P<0.05)。2组患者药物的不良反应率分别为18.92%和23.68%,差异无统计学意义(P>0.05)。结论:丙戊酸镁用于防治偏头痛安全有效。

Effect of magnesium valprote in the treatment of migraine

Objective:To explore the effects and safety of magnesium valproate in the treatment of migraine.Methods:Eighty-one patients with migraine(including miss follow-up 6 cases) were randomly divided into the flunarizine group(37 cases treated with flunarizine) and magnesium valprote group(38 cases treated with magnesium).Compared with before treatment, the frequency of headache attack and severity of headache in two groups after 3 months of treatment were analyzed.Results:Compared with before treatment, the frequency of headache attack in two groups decreased significantly(P<0.01), and the difference of which between two groups was not statistically significant after treatment(P>0.05).Compared with before treatment, the scores of headache severity in two groups decreased significantly(P<0.01), and the difference of which between two groups was statistically significant after treatment(P>0.05).The incidences of adverse reactions in flunarizine group and magnesium valprote group were 18.92% and 23.68%, respectively, the difference of which was not statistically significant(P>0.05).Conclusions:Magnesium valproate treating migraine is secure and effective.