| 薄膜包衣工艺制备苦参总碱控释微丸的研究 |
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| 引用本文： | 时军,程怡,李学涛.薄膜包衣工艺制备苦参总碱控释微丸的研究[J].中药材,2007,30(12):1601-1603. |
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| 作者姓名： | 时军 程怡 李学涛 |
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| 作者单位： | 广州中医药大学中药学院,广东广州,510045 |
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| 摘 要： | 目的:薄膜包衣工艺制备苦参总碱控释微丸。方法:采用GPCG-1型流化床包衣设备和乙基纤维素水分散体对苦参总碱液投入包衣,进行药物体外释放度研究和外观考察。结果:包衣微丸外观光洁,成膜均匀,体外释放符合零级动力学方程。结论:薄膜包衣工艺制备苦参总碱控释微丸方法可行,控释效果良好。
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| 关 键 词： | 薄膜包衣工艺 苦参总碱 控释微丸 |
| 文章编号： | 1001-4454（2007）12-1601-03 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007年4月23日 |
Preparation of Total Matrine Controlled Release Micropellet Capsules |
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| SHI Jun,CHENG Yi,LI Xue-tao.Preparation of Total Matrine Controlled Release Micropellet Capsules[J].Jorunal of Chinese Medicinal Materials,2007,30(12):1601-1603. |
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| Authors: | SHI Jun CHENG Yi LI Xue-tao |
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| Institution: | Department of Pharmarey, Guangzhou University of Chinese Medicine, Guangzhou 510045, China |
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| Abstract: | Objective:To prepare total matrine controlled release micropellet capsules.Methods:The capsules were prepared by the technology of film-coating with surelease as matrix,and judged by the release behavior.Results:The drug had completely been coated into a homogeneous and continuous film,and the results repeated in three batches showed that the release behavior of the pellet capsules followed zero-equation.Conclusion:The capsules have good sustained release effect and the process of the preparation is available. |
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| Keywords: | Film-coating technology Total matrine Controlled release micropellet |
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