三七总皂甙注射液治疗肺源性心脏病急性发作期心力衰竭疗效观察

目的：观察三七总皂甙注射液联用西药治疗肺源性心脏病（肺心病）急性发作期心力衰竭（心衰）的疗效。方法：６０ 例患者随机分为２ 组，每组３０ 例。对照组给予吸氧、抗生素、氨茶碱、利尿剂和地塞米松等治疗；治疗组除以上治疗外加用三七总皂甙注射液６００ ｍ ｇ 加入５％ 葡萄糖或生理盐水中静滴，每日１ 次，２ 组均连续用药１５ 日后评定疗效、心功能和血气分析。结果：治疗组显效率（５６７％ ）、总有效率（９３３％ ）显著高于对照组（分别为３６７％ 和７６７％ ， Ｐ＜ ００１ 和 Ｐ＜ ００５）。治疗组治疗后肺动脉平均压（ Ｐ Ａ Ｍ Ｐ）、肺血管阻力（ Ｐ Ｖ Ｒ）、总外周血管阻力（ Ｔ Ｐ Ｒ）、 Ｐａ Ｏ２ 和动脉血氧饱和度（ Ｓａ Ｏ２）的改善明显优于对照组（ Ｐ＜ ００５ 或 Ｐ＜ ００１）。结论：三七总皂甙注射液与西药合用治疗肺心病急性发作期心衰比单用西药治疗更加有效和安全。

Observations on curative effects of panax notoginseag total saponin injection on heart failure of acute seizure phase of cor pulmonale

Objective:To observe the curative effects of panax notoginseag total saponin (PNTS) injection combined with western medicine (WM) on heart failure of acute seizure phase of cor pulmonale.Methods:60 patients were randomly divided into two groups.The control group ( n =30) was treated with inhaling oxygen,antibiotics,aminophylline,diuretics and dexamethglucose or normal saline infused intravenously once a day besides abovementioned therapy.In two groups after 15 days continuous therapy the judgement for curative effects,cardiac functions and blood gas analysis was carried out.Results:In treatment group the markedly effective rate (56 7%) and total effective rate (93 3%) were significantly higher than those (36 7% and 76 7%) respectively in control group ( P <0 01 and P <0 05).The differences between treatment group and control group in pulmonary arterial mean pressure (PAMP) and pulmonary vascular resistance (PVR) were significant (all P <0 01),otherwise the differences in total peripheral resistance (TPR),PaO 2,and arterial oxygen saturation(SaO 2) were significant too (all P <0 05).Conclusions:The treatment with PNTS injection combined with western medicine for heart failure of acute seizure phase of cor pulmonale in comparison with western medicines alone is much more effective and safer.