| 神经生长因子和碱性成纤维细胞生长因子联用治疗坐骨神经损伤实验研究 |
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| 引用本文： | 梁崇礼,赵稳兴. 神经生长因子和碱性成纤维细胞生长因子联用治疗坐骨神经损伤实验研究[J]. 中国组织工程研究与临床康复, 2003, 7(6): 1012-1013 |
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| 作者姓名： | 梁崇礼 赵稳兴 |
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| 作者单位： | DepartmentofMedicalExperiment，KunmingGeneralHospitalofChengduMilitaryofPLA，DepartmentofMedicalExperiment，KunmingGeneralHospitalofChengduMilitaryofPLA Kunming650032，YunnanProvince，China，Kunming650032，YunnanProvince，China |
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| 摘 要： | INTRODUCTIONNowdays,manynervenutrientfactorswerefoundtohaverepaireffectonnerveinjury犤1.However,manyexperimentshaveconcen-tratedontheeffectofsinglefactor.Ourresearchwerefocusedoncombinationeffectofnervegrowthfactor(NGF)andbasicfibrob-lastgrowthfactor(bFGF)onsciaticnerveinjuryandprovidecluestoclinicaltreatment.MATERIALSANDMETHODSMaterialsExperimentanimalsandgroupdivision96femaleWistarrats,weighting220-240gwererandomlydividedintonormalsalinegroup,NGFgroup,bFGFgroupandNGF+bFGF…
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Experimental research of curing sciatic nerve injury using nerve growth factor and basic fibroblast growth factor combination |
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| Liang Congli,Zhao WenxingLiang Congli,Zhao Wenxing. Experimental research of curing sciatic nerve injury using nerve growth factor and basic fibroblast growth factor combination[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(6): 1012-1013 |
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| Authors: | Liang Congli Zhao WenxingLiang Congli Zhao Wenxing |
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| Affiliation: | Department of Medical Experiment,Kunming General Hospital of Chengdu Military of PLA, Kunming 650032,Yunnan Province, China |
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| Abstract: | AIM:To explore the co effect of nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) on the sciatic nerve after injury. METHODS: 96 rats were divided into normal saline group, NGF group, bFGF group and NGF+bFGF group. Sciatic nerve function index (SFI), nerve conduction velocity, regeneration axon counting were detected in the 3 rd, 6 th, 9 th, 12 th week postinjury. RESULTS:The end of SFI, nerve conduction velocity, regeneration axon counting in NGF+bFGF group were higher than those in the other groups. CONCLUSION:The co effect of NGF and bFGF on sciatic nerve is better than the effect of NGF or bFGF alone. |
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| Keywords: | nerve growth factor basic fibroblast growth factor nerve injury |
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