初发2型糖尿病患者并发勃起功能障碍的病例对照分析

目的：探讨初发2型糖尿病(T2DM)患者并发勃起功能障碍(ED)的多种影响因素。方法：应用1：1配对病例对照研究，顺序收集57例初发T2DM合并ED的患者作为病例组，同期初发T2DM未合并ED的患者57例作为对照组，一对内年龄相差不超过2岁。对体重指数(BMI)、空腹血糖(FPG)、口服葡萄糖耐量实验(OGTT)2h血糖(2hPG)、空腹血胰岛素(INS)、空腹C-肽、糖化血红蛋白(HbAlc)、血清睾酮(T)、雌二醇(E2)、睾酮／雌二醇(T／E2)、血清一氧化氮(NO)、红细胞醛糖还原酶(AR)、吸烟、酗酒、伴发疾病(包括高血压、高脂血症、高尿酸血症、心脏疾病、肝脏疾病等)、其他慢性并发症(糖尿病神经病变、糖尿病视网膜病变、糖尿病肾病等)、药物使用(包括B受体阻滞剂、钙通道阻滞剂、血管紧张素转换酶抑制剂及利尿剂等可影响勃起功能的药物)等进行分析。结果：BMI、FPG、2hPG、INS、HbAlc、AR、NO、伴发疾病、并发症以及药物使用在两组间差异有显著性(P<0．05)。结论：初发T2DM患者并发勃起功能障碍是多种因素作用的结果。

A case- control study in patients with type 2 diabetic erectile dysfunction

Objective To investigate the effect factors on type 2 diabetic erectile dysfunction (ED). Methods A questionnaire survey, physical examination, and laboratory examination were conducted in 114 type 2 diabetes mellitus (T2DM)patients. They were divided into 57 ED cases and age-mated no-ED cases . Some factors including age, body mass index (BMI), fasting plasma glucose (FPG), 2hPG, insulin (INS), HbA1c, C-peptide, nitric oxide (NO), testosterone (T), estradiol (E2), the ratio of testosterone to estradiol (T/E2), erythrocyte aldose reductase (AR), drinking, smoking, complication, treatment and concomitant disease were analysed. Results There are significant difference between ED and no-ED group on BMI, FPG, 2hPG, INS, HbA1c, AR, NO, concomitant disease, complication, medicationn(P< 0.05). Conclusion ED results from muti-factors in T2DM.