A new myocardial imaging agent: synthesis, characterization, and biodistribution of gallium-68-BAT-TECH |
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| Authors: | H F Kung B L Liu D Mankoff M P Kung J J Billings L Francesconi A Alavi |
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| Affiliation: | Department of Radiology, University of Pennsylvania, Philadelphia 19104. |
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| Abstract: | In order to develop a new myocardial perfusion agent for positron emission tomography (PET), a new lipid-soluble gallium complex was evaluated. Synthesis, radiolabeling, characterization, and biodistribution of a unique gallium complex, [67Ga]BAT-TECH (bis-aminoethanethiol-tetraethyl-cyclohexyl), are described. The complex formation between Ga+3 and BAT-TECH ligand is simple, rapid, and of high yield (greater than or equal to 95%). This process is amenable to kit formulation. The complex has a net charge of +1 and a Ga/ligand ratio of 1:1. Biodistribution in rats shows high uptake in the heart as well as in the liver. When [68Ga] BAT-TECH was injected into a monkey, the heart and liver are clearly delineated by PET imaging, suggesting that this complex may be a possible tracer for myocardial perfusion imaging. |
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