| 注射型原位凝胶植入剂的研究进展 |
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| 引用本文： | 董吉,蒋曙光,平其能. 注射型原位凝胶植入剂的研究进展[J]. 药学进展, 2007, 31(3): 109-113 |
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| 作者姓名： | 董吉 蒋曙光 平其能 |
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| 作者单位： | 中国药科大学药剂学教研室,江苏,南京210009 |
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| 摘 要： | 综述以聚乳酸，聚乳酸-乙醇酸共聚物（PLA/PLGA）、醋酸-异丁酸蔗糖酯（SAIB）、有机凝胶和PLA／PLGA与PEG的三嵌段共聚物为载体的注射型原位凝胶植入剂的研究进展，包括其特性、释药机制、制备和应用。这种新型给药系统已成为近年来非胃肠给药研究的热点之一。
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| 关 键 词： | 原位凝胶植入剂 聚合物 载体 控释 |
| 文章编号： | 1001-5094（2007）03-0109-05 |
| 收稿时间： | 2006-12-15 |
| 修稿时间： | 2006-12-15 |
Development of Injectable Biodegradable in-situ Forming Gel Implants |
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| DONG Ji,JIANG Shu-guang,PING Qi-neng. Development of Injectable Biodegradable in-situ Forming Gel Implants[J]. Progress in Pharmaceutical Sciences, 2007, 31(3): 109-113 |
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| Authors: | DONG Ji JIANG Shu-guang PING Qi-neng |
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| Affiliation: | Department of Pharmaceutics , China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | The development of injectable biodegradable in-situ forming gel implants based on PLA/PLGA, SAIB, organic gel or PLA/PLGA-PEG tribleck copolymers as carriers, including their characteristics , drug release mechanism, preparation and application, was reviewed. The novel drug delivery system has become a spotlight of the research on parenteral drug delivery in recent years. |
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| Keywords: | In-situ forming gel implant Copolymer Carrier Controlled release |
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