Analysis of B. Malayi Microfilarial Antigens by Immunoblotting |
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| Authors: | P B Parab G R Rajasekariah P A Carvalho D Subrahmanyam |
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| Institution: |
a Pharma Division, Research Centre, HINDUSTAN CIBA-GEIGY Ltd., Bombay, India
b Research Department, Pharmaceutical Division, CIBA-GEIGY Ltd., Basle, Switzerland |
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| Abstract: | BALB/C mice were immunized with heavy or low infection of live B. malayi microfilariae or immunised with different fractions of the microfilarial antigens. Antibody levels and antibody dependent macrophage mediated cytotoxicity to B. malayi microfilariae were determined in the immunized sera. Antigens responsible for induction of antibodies were recognised in B. malayi microfilarial extract by immuno blotting. Appearance of cytotoxic antibodies correlates with recognition of certain common antigens in microfilarial extract such as 45, 54, 62, 66 and 76 KDa mol. wt. proteins. |
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