| 染料木素的神经保护作用及其机制的研究进展 |
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| 引用本文： | 罗思婧,黄庆,任冬冬,廖维良,杨红. 染料木素的神经保护作用及其机制的研究进展[J]. 广东药学院学报, 2011, 27(1): 94-98. DOI: 10.3969/j.issn.1006-8783.2011.01.024 |
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| 作者姓名： | 罗思婧 黄庆 任冬冬 廖维良 杨红 |
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| 作者单位： | 1. 广东药学院,基础学院,广东,广州,510006
2. 广州市拜澳生物科技有限公司,广东,广州,510630 |
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| 基金项目： | 广东省社会发展计划工业攻关项目，广东省科技计划农业攻关项目 |
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| 摘 要： | 染料木素广泛存在于豆科植物中,其作为植物雌激素应用于制药、营养保健品等领域.研究表明,染料木素可以通过抗氧化、抗AB毒性、调节神经营养因子的表达、调节细胞内Ca2+浓度、减轻谷氨酸的神经毒性、抑制神经细胞的凋亡、调节信号转导通路以及增加海马神经肽Y的表达等作用机制,从而发挥神经保护作用.本文综述染料木素的神经保护作用及...
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| 关 键 词： | 染料木素 神经保护 阿尔茨海默病 |
Research progress on neuroprotective effect and its mechanisms of genistein |
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| LUO Si-jing,HUANG Qing,BEN Dong-dong,LIAO Wei-liang,YANG Hong. Research progress on neuroprotective effect and its mechanisms of genistein[J]. Academic Journal of Guangdong College of Pharmacy, 2011, 27(1): 94-98. DOI: 10.3969/j.issn.1006-8783.2011.01.024 |
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| Authors: | LUO Si-jing HUANG Qing BEN Dong-dong LIAO Wei-liang YANG Hong |
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| Affiliation: | 1(1.Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China;2.Guangzhou Biours Biosciences Co.Ltd.,Guangzhou,Guangdong 510630,China) |
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| Abstract: | Genistein widely exists in legumes, and as a phytoestrogen, is applied in pharmaceutical industry, nutritional products and so on. It is proved that genistein has neuroprotective effects through the mechanisms of anti-oxidation, resisting A beta（Aβ） toxicity, adjusting neurotrophic factor expression, regulating intracellular Ca2＋ concentration, reducing the neuro-toxicity of glutamine, inhibiting the nerve cell apoptosis, regulating signal transduction pathway and increasing the hippocampus neuropeptide Y expression, etc. Based on domestic and overseas scholars＇ researches in recent years on the treatment of Alzheimer＇s disease （AD） with genistein, developments of the neuroprotective effects of genistein are reviewed. |
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| Keywords: | genistein neuroprotective effect Alzheimer＇ s disease |
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