| 灯盏花素的溶解度与油水分配系数的测定 |
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| 引用本文： | 卢秀霞,何琳,陈莉,吴伟昂,史锐标,龙晓英.灯盏花素的溶解度与油水分配系数的测定[J].广东药学院学报,2011,27(1):1-4. |
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| 作者姓名： | 卢秀霞 何琳 陈莉 吴伟昂 史锐标 龙晓英 |
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| 作者单位： | 广东药学院,中山校区,广东,中山,528458 |
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| 基金项目： | 国家自然科学基金面上项目 |
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| 摘 要： | 目的 考察灯盏花素的平衡溶解度与油水分配系数,为制剂研究奠定基础.方法 采用摇瓶-紫外分光光度法测定灯盏花素在水、不同pH值磷酸盐缓冲液中的平衡溶解度及其油水分配系数.结果 灯盏花索在水及pH1.0、2.0、3.0、4.0、5.0、6.0、6.5磷酸盐缓冲液中的平衡溶解度分别为212.088、2.801、2.812、3...
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| 关 键 词： | 灯盏花素 平衡溶解度 油水分配系数 |
Determination of equilibrium solubility and Oil-water partition coefficient of scutellarin |
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| LU Xiu-xia,HE Lin,CHEN Li,WU Wei-ang,SHI Rui-biao,LONG Xiao-ying.Determination of equilibrium solubility and Oil-water partition coefficient of scutellarin[J].Academic Journal of Guangdong College of Pharmacy,2011,27(1):1-4. |
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| Authors: | LU Xiu-xia HE Lin CHEN Li WU Wei-ang SHI Rui-biao LONG Xiao-ying |
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| Institution: | (Guangdong Pharmaceutical College,Zhongshan,Guangdong 528458,China) |
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| Abstract: | Objective To investigate the equilibrium solubility and the oil-water partition coefficient of scutellarin laying the foundation for the research of its preparations. Methods The equilibrium solubility and the oil-water partition coefficient of scutellarin in water and different phosphate buffers were measured by shaking flask-UV spectrophotometry. Results The equilibrium solubility of seutellarin in water, pH 1.0,2.0,3.0,4.0,5.0,6.0 and 6.5 phosphate buffer were 212. 088,2. 801,2. 812,3. 413,4. 758,48. 047,424. 167 and 5 675. 584 μg/ mL, and the oil-water partition coefficients were 0. 923,1.931,1. 753,1. 350,0. 826,0. 525,0. 222 and 0. 212 respectively. Conclusion The determination method is easy and feasible. Scutellarin is slightly soluble in water at 37 ℃ ,the solubility of which increases as pH value goes up and the oil-water partition coefficient is reduced. |
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| Keywords: | scutellarin equilibrium solubility oil-water partition coefficient |
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