探讨儿童外周血异型淋巴细胞增多的病原学及临床动态变化特点

目的探讨儿童外周血异型淋巴细胞增多的病原学及临床动态变化特点。方法对60例外周血液涂片异型淋巴细胞〉2％的患儿，应用聚合酶链反应（PCR）法检测EB病毒DNA、巨细胞病毒DNA及乙肝表面抗原病毒DNA；采用咽拭子分泌物PCR法检测支原体DNA；酶联免疫吸附试验检测腺病毒IgM抗体、EB病毒IgM抗体；同时进行咀液涂片及瑞氏染色，对异型淋巴细胞进行记数并按病程进行动态观察。结果49例（81．7％）患儿被检出有病毒或支原体感染；EB病毒、巨细胞病毒感染引起的异型淋巴细胞增多所占百分比较高，恢复正常所需时间亦较长，其他感染所占百分比较低，恢复正常所需时间较短。结论引起儿童外周血异型淋巴细胞增多的病原除EB病毒、巨细胞病毒、支原体、腺病毒外，其他感染亦会引起其增多，其中以EB病毒所占比例最多；不同的疾病中出现的异型淋巴细胞数量有很大的差异性，并随病程的发展而发生动态变化。

Etiology and dynamic changes of increased peripheral atypical lymphocytes

Objective To observe the etiology and the dynamic changes of increased peripheral atypical lymphocytes in child. Methods Sixty-one children was enrolled. EBV-DNA,CMV-DNA,Hepatitis B-DNA were detected by PCR test. Results Forty nine of the samples(82% ) were infected by virus or mycoplasma, EBV、CMV. Other infection causes were rare. Conclusion In addition to EBV, CVB, CMV, MP, AdV infection can cause lymphocytes incensement.