| 微管相关蛋白Tau磷酸化及其靶向抑制作用研究进展 |
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| 引用本文： | 周付涛,陈双容,孙学川. 微管相关蛋白Tau磷酸化及其靶向抑制作用研究进展[J]. 生物医学工程学杂志, 2012, 0(4): 788-792 |
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| 作者姓名： | 周付涛 陈双容 孙学川 |
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| 作者单位： | 南昌航空大学体育学院;解放军军事体育进修学院 |
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| 摘 要： | 进行性遗忘是阿尔茨海默病(AD)的主要临床表现,微管相关蛋白Tau(MAPT)高度磷酸化在AD和其它神经退变性疾病中扮演着关键性角色。本文拟从参与Tau蛋白磷酸化的激酶和磷酸酶以及基于靶向Tau激酶抑制和磷酸酶激活的治疗策略方面展开综述。
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| 关 键 词： | Tau蛋白 Tau蛋白激酶 Tau蛋白磷酸酶 靶向抑制 |
Research Progress of Abnormal Phosphorylation of Microtubule-associated Tau Protein and of the Targeted Inhibition of the Phosphorylation |
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| Zhou Futao,Chen Shuangrong,Sun Xuechuan. Research Progress of Abnormal Phosphorylation of Microtubule-associated Tau Protein and of the Targeted Inhibition of the Phosphorylation[J]. Journal of biomedical engineering, 2012, 0(4): 788-792 |
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| Authors: | Zhou Futao Chen Shuangrong Sun Xuechuan |
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| Affiliation: | 1(School of Physical Education,Nanchang Hangkong University,Nanchang 330063,China) 2(PLA Institute of Physical Education,Guangzhou 510502,China) |
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| Abstract: | Progressive dementia is described as the first and most prominent symptom of Alzheimer’s disease(AD),and hyperphosphorylation of microtubule associated Tau protein(MAPT) plays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases.This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein,and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases. |
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| Keywords: | Tau protein Tau kinases Tau phosphatases Targeted inhibition |
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