| 恶性组织细胞增生症的免疫组化─20例尸解研究 |
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| 引用本文： | 杨怀涛,李甘地,杨秀英,刘开凤. 恶性组织细胞增生症的免疫组化─20例尸解研究[J]. 诊断病理学杂志, 1995, 0(1) |
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| 作者姓名： | 杨怀涛 李甘地 杨秀英 刘开凤 |
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| 作者单位： | 华西医科大学口腔病理学教研室，华西医科大学病理学教研室 |
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| 摘 要： | 本文用能特异标记福尔马林固定、石蜡包埋组织中的Ｔ、Ｂ细胞及组织细胞的三种单克隆抗体（ＵＣＨＬ１、Ｌ２６及Ｍａｃ３８７），对２０例尸解恶性组织细胞增生症进行免疫组化染色，结果发现有１８例为ＵＣＨＬ１确切阳性。结果表明恶组其实绝大部分为Ｔ细胞源性肿瘤，而真正的恶组非常罕见。
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| 关 键 词： | 恶性组织细胞增生症；T细胞；免疫组化 |
An immunohistochemical study of 20 cases of malignant histiocytosis on autopsy |
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| Yang Huaitao, Li Gandi, Yang Xiuying, et al. An immunohistochemical study of 20 cases of malignant histiocytosis on autopsy[J]. Chinese Journal of Diagnostic Pathology, 1995, 0(1) |
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| Authors: | Yang Huaitao Li Gandi Yang Xiuying et al |
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| Abstract: | For several decades, the malignant histiocytosis (MH) had been regarded as a tumor that was derived from histiocyte. Recently, a few authors considered that the MH was a lymphocyte - derived tumor. In our research, the lymphocytes and histiocytes were labelled by ABC immunohistochemical method with three monoclonal antibodies that are specific for T cell (UCHL1), B cell (L26) and histiocyte (Mac387) in formalin - fixed paraffin -embedded tissue sections respectively. It was found that 18 out of 20 cases of MH on autopsy were positively stained with UCHL1. This result demonstrates that the so -called MH is in fact a T -lineage tumor, and the true MH is very rare. |
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| Keywords: | Malignant histiocytosis T -cell Immunohistochemistry |
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