| 注意缺陷多动障碍儿童反应抑制功能的磁共振成像研究 |
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| 引用本文： | 刘冬柏,董选,王苏弘,陈杰,邢伟,任艳玲. 注意缺陷多动障碍儿童反应抑制功能的磁共振成像研究[J]. 中华精神科杂志, 2008, 41(2) |
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| 作者姓名： | 刘冬柏 董选 王苏弘 陈杰 邢伟 任艳玲 |
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| 作者单位： | 1. 苏州大学附属第三医院脑科学研究中心,常州,213003
2. 苏州大学附属第三医院影像科,常州,213003 |
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| 基金项目： | 国家自然科学基金，苏州大学校科研和教改项目 |
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| 摘 要： | 目的 探讨注意缺陷多动障碍(ADHD)儿童执行高级反应抑制脑激活的模式和功能状态.方法 对12例注意缺陷多动障碍儿童(ADHD组)和12名正常对照者(对照组)检测执行持续性操作测试任务(CPT)时的功能磁共振成像(fMRT)和行为学,并采集全脑血氧水平依赖对比的fMRI扫描数据.结果 (1)行为学检测,ADHD组的击中数[(18.6±4.1)个]少于对照组[(22.8±1.8)个],反应时间[(579±56)ms]长于正常对照组[(510±35)ms;均P＜0.01],漏击数[(6.3±4.1)个]和错击数[(3.9±2.4)个]均多于对照组[(2.2±1.9)个和(1.9±1.0)个;P＜0.01～0.05].(2)fMRI检测,ADHD组扣带前回、前额叶腹外侧、尾状核和小脑激活弱于对照组(P＜0.05,未校正,体素值＞20).结论 ADHD儿童反应抑制功能存在缺陷,其扣带前回、前额叶、基底节及小脑的功能低下.
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| 关 键 词： | 注意力缺陷障碍伴多动 磁共振成像 反应抑制 持续性操作测试 |
Functional magnetic resonance imaging study of response inhibition in children with attention-deficit hyperactivity disorder |
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| Abstract: | Objective To study the brain activation and functional station when performing highlevel response inhibition in children with attention-deficit hyperactivity disorder(ADHD).Methods Eventrelated designed BOLD functional magnetic resonance imaging scan covering the whole brain was conducted in 12 right-handed children with ADHD and 12 normal children.The continuous performance test(CPT)Wag used as activation task.Results The ADHD children had lower hit numbers and longer reaction time than controls(JP＜0.01),with more missed(6.3 4±4.1)and false alarms(3.9±2.4)than controls [(2.2±1.9).(1.9 4±1.0):P＜0.01-0.05].ADHD children showed decreased activations in anterior eingulate cortex(dACC),ventrolateral prefrontal cortex(VLPFC),caudate nucleus and cerebellum (dACC)(P＜0.05.uncorrected.voxel＞20).Conclusion The children with ADHD have response inhibition impairment,and decreased activation in anterior cingulate cortex,prefrontal cortex,basal ganglia and cerebellum. |
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| Keywords: | Attention deficit disorder with hyperactivity Magnetic resonarlce imaging Reactive inhibition Continuous performance test |
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