Beneficial effects of magnolol in a rodent model of endotoxin shock |
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Authors: | Yung-Chieh Tsai Pao-Yun Cheng Yi-Jen Peng Jhi-Joung Wang |
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Institution: | a Center for Reproductive Medicine, Chi-Mei Foundation Hospital, Tainan, Taiwan b Department of Biotechnology, Southern Taiwan University of Technology, Tainan, Taiwan c Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan d Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan e Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan f Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan g Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan |
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Abstract: | Magnolol is a compound extracted from the Chinese medicinal herb Magnolia officinalis. It has multiple pharmacological effects, notably as an anti-oxidant. The aim of this study was to evaluate the effects of magnolol on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS; 10 mg/kg) in anaesthetized Wistar rats. Magnolol (4 μg/kg, i.v.) was administered at 30 min after LPS injection. Post-treatment with magnolol significantly attenuated the deleterious haemodynamic changes (e.g., hypotension and bradycardia) caused by LPS. Meanwhile, magnolol significantly inhibited the elevation of plasma levels of tumor necrosis factor alpha, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and blood urine nitrogen caused by LPS. The induction of inducible nitrous oxide (NO) synthase and the overproduction of NO and superoxide anions by LPS were also significantly reduced by post-treatment with magnolol. Moreover, the plasma level of the thrombin-antithrombin complex following administration of LPS was also reduced by post-treatment with magnolol. Thus, the beneficial effects of magnolol on LPS-induced sepsis result from its anti-inflammatory, anti-coagulatory, and anti-oxidant effects. |
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Keywords: | Magnolol Reactive oxygen species Sepsis TNF-α Nitric oxide Circulatory failure |
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