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| Intraperitoneal dedifferentiated liposarcoma： A case report | |
| 作者姓名： | Karaman A Kabalar ME Ozcan O Koca T Binici DN |
| 作者单位： | Department of Medical Genetics;State Hospital;Erzurum 25240;Turkey;Department of Pathology;Department of General Surgery;Department of Radiation Oncology;Department of Internal Medicine; |
| 摘 要： | Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed, p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported thatp53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum. |
| 关 键 词： | 腹膜内反分化脂肪肉瘤 p53基因 基因突变 基因治疗 |
| 收稿时间： | 2008 Jun 30 |
Intraperitoneal dedifferentiated liposarcoma: a case report |
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| Karaman A,Kabalar ME,Ozcan O,Koca T,Binici DN.Intraperitoneal dedifferentiated liposarcoma: a case report[J].World Journal of Gastroenterology,2008,14(38):5927-5929. | |
| Authors: | Karaman Ali Kabalar Mehmet-Esref Ozcan Onder Koca Timur Binici Dogan-Nasir |
| Institution: | 1. Department of Medical Genetics, State Hospital, Erzurum 25240, Turkey 2. Department of Pathology, State Hospital, Erzurum 25240, Turkey 3. Department of General Surgery, State Hospital, Erzurum 25240, Turkey 4. Department of Radiation Oncology, State Hospital, Erzurum 25240, Turkey 5. Department of Internal Medicine, State Hospital, Erzurum 25240, Turkey |
| Abstract: | Declifferentiated liposarcoma is a wriant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed, p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum. |
| Keywords: | Dedifferentiated liposarcoma p53 gene Mutation Intraperitoneum |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |