Three-dimensional analysis of tooth dimensions in the <Emphasis Type="Italic">MSX1</Emphasis>-missense mutation |
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Authors: | Marijn Créton Marie-José van den Boogaard Thomas Maal Luc Verhamme Willem Fennis Carine Carels Anne Marie Kuijpers-Jagtman Marco Cune |
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Institution: | 1.Department of Oral and Maxillofacial Surgery, Prosthodontics and Special Dental Care,University Medical Centre Utrecht,Utrecht,The Netherlands;2.Department of Medical Genetics,University Medical Center Utrecht,Utrecht,The Netherlands;3.Department of Oral and Maxillofacial Surgery,Radboud University Nijmegen Medical Centre,Nijmegen,The Netherlands;4.Department of Orthodontics and Craniofacial Biology,Radboud University Nijmegen Medical Centre,Nijmegen,The Netherlands;5.Department of Oral-Maxillofacial Surgery, Prosthodontics and Special Dental Care,St. Antonius Hospital,Nieuwegein,The Netherlands;6.Department of Fixed and Removable Prosthodontics, Centre for Dentistry and Oral Hygiene, University Medical Center Groningen,The University of Groningen,Groningen,The Netherlands |
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Abstract: | ObjectivesA novel, 3D technique to measure the differences in tooth crown morphology between the MSX1 cases and non-affected controls was designed to get a better understanding of dental phenotype-genotype associations.Materials and methodsEight Dutch subjects from a single family with tooth agenesis, all with an established nonsense mutation c.332 C > A, p. Ser 111 Stop in exon 1 of MSX1, were compared with unaffected controls regarding several aspects of tooth crown morphology of incisor and molar teeth. A novel method of quantitative three-dimensional analysis was used to detect differences.ResultsStatistically significant shape differences were observed for the maxillary incisor in the MSX1 family compared with the controls on the following parameters: surface area, buccolingual dimension, squareness, and crown volume (P?≤?0.002). Molar crown shape was unaffected.ConclusionsA better understanding of dental phenotype-genotype associations may contribute to earlier diagnosis of some multiple-anomaly congenital syndromes involving dental anomalies.Clinical relevanceA “shape database” that includes associated gene mutations resulting from developmental syndromes may facilitate the genetic identification of hypodontia cases. |
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