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Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency |
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| Authors: | Zafeiris Zafeiriou Diletta Bianchini Robert Chandler Pasquale Rescigno Wei Yuan Suzanne Carreira Maialen Barrero Antonella Petremolo Susana Miranda Ruth Riisnaes Daniel Nava Rodrigues Bora Gurel Semini Sumanasuriya Alec Paschalis Adam Sharp Joaquin Mateo Nina Tunariu Arul M. Chinnaiyan Johann S. de Bono |
| Affiliation: | 1. The Institute of Cancer Research, The Royal Marsden, London, United Kingdom;2. Theageneion Anticancer Hospital, Thessaloniki, Greece;3. Department of Clinical Medicine and Surgery, Department of Translational Medical Sciences, AOU Federico II, Naples, Italy;4. Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA;5. Department of Laboratory Medicine, University of Washington, Seattle, WA, USA;6. Sidney Kimmel School of Medicine at Thomas Jefferson University, Philadelphia, PA, USA |
| Abstract: | Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP)-ribose polymerase inhibition and platinum, has increased interest in the utilisation of these drugs against a subset of these diseases. Here in we report three patients with advanced castration-resistant PCa with HRD defects having exceptional responses to carboplatin. |
| Keywords: | Prostate cancer Homologous recombination defects Platinum DNA repair genes |
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