| 尾加压素Ⅱ的非血流动力学作用及其在某些疾病中的意义 |
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| 引用本文： | 陈素贤,罗萍,李才.尾加压素Ⅱ的非血流动力学作用及其在某些疾病中的意义[J].中国病理生理杂志,2007,23(8):1654-1657. |
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| 作者姓名： | 陈素贤 罗萍 李才 |
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| 作者单位： | 吉林大学再生医学科学研究所病理学研究室,吉林 长春 130021 |
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| 摘 要： | 尾加压素Ⅱ(urotensinⅡ,UⅡ)是迄今发现的体内最强的缩血管活性肽,其缩血管效应是内皮素-1(ET-1)的10倍多1]。1998年UⅡ首次被从人体中克隆出来2]。1999年Ames等1]首次发现人体中一种孤立的G蛋白偶联受体GPR14(UT)是UⅡ的特异性受体,两者结合可发挥多种生物学效应。由于UⅡ
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| 关 键 词： | 尿紧张素类 非血流动力学 |
| 文章编号： | 1000-4718（2007）08-1654-04 |
| 收稿时间： | 2005-11-16 |
| 修稿时间： | 2005-11-16 |
Nonhemodynamic effect of urotensin- Ⅱ and its significance in some diseases |
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| CHEN Su-xian,LUO Ping,LI Cai.Nonhemodynamic effect of urotensin- Ⅱ and its significance in some diseases[J].Chinese Journal of Pathophysiology,2007,23(8):1654-1657. |
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| Authors: | CHEN Su-xian LUO Ping LI Cai |
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| Institution: | Department of Pathology,Institute of Frontier Medical Science,Jilin
University,Changchun 130021,China |
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| Abstract: | Urotensin-Ⅱ is the most potent vasoconstrictor peptide ever identified.A great number of studies about hemodynamics of urotensin-Ⅱ were reported.Recently,many researches have demonstrated that urotensin-Ⅱ also has nonhemodynamic effects,such as mitogenic action,stimulating cell proliferation,promoting extracellular matrix production and so on.Nonhemodynamic effects of urotensin-Ⅱ may play a role in the pathogenesis of some diseases. |
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| Keywords: | Urotensins Nonhemodynamics |
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