时间差攻击疗法治疗下呼吸道多重耐药铜绿假单胞菌感染疗效观察

目的：探讨时间差疗法治疗下呼吸道多重耐药铜绿假单胞菌感染的疗效。方法：将有多重耐药铜绿假单胞菌感染的病例随机分为实验、对照两组，实验组采用磷霉素与头孢哌酮-舒巴坦时间差攻击疗法，对照组采用磷霉素与头孢哌酮-舒巴坦同时联合疗法。结果：治疗14 d 后，实验组的有效率为85.71%，对照组为65.12%。经χ2检验，有显著性差异（P ＜0.05）。结论：时间差攻击疗法疗效好，为多重耐药铜绿假单胞菌感染提供了一种新的治疗方法。

Curative Effect Observation on Time Difference Attack Therapy in the Treatment of Lower Respiratory Tract Infection Caused by Multidrug-Resistant Pseudomonas Aeruginosa

Objective：To evaluate the curative effect of time difference attack therapy in the treatment of lower respiratory tract infection caused by multidrug-resistant pseudomonas aeruginosa. Methods： To divide the patients in-fected by multidrug-resistant pseudomonas aeruginosa into experimental group and control group randomly. The experi-mental group took fosfomycin and cefoperazone sulbactam at different time, and control group took the same drugs at the same time. Results： Fourteen days later, the clinical effective incidence of experimental group was 85.71%, while the incidence of control group was 65.21%. By χ2 test , the difference was statistically significant（P 〈 0.05）. Con-clusion： Time difference attack therapy showed a better effect and presented as a new method for the treatment of mul-tidrug-resistant pseudomonas aeruginosa infection.