| E-cadherin与Snail在涎腺腺样囊性癌中的表达及意义 |
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| 引用本文： | 李玉旺,南欣荣,令狐清溪. E-cadherin与Snail在涎腺腺样囊性癌中的表达及意义[J]. 中国现代医生, 2010, 48(4): 14-15,26,F0003 |
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| 作者姓名： | 李玉旺 南欣荣 令狐清溪 |
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| 作者单位： | 山西医科大学第一医院,山西太原,030001 |
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| 摘 要： | 目的研究E—cadherin与Snail在人腺样囊性癌（SACC）中的表达及临床意义。方法用免疫组化的方法检测E—cadherin与Snail在SACC及正常涎腺组织中的表达。结果（1）与正常涎腺组织相比，E-cadherin在SACC中表达下降，差异有统计学意义（P〈0．05），E—cadherin表达与不同组织病理学类型有关，且在发生神经侵犯及远处转移的病例中，E—cadherin表达下降更明显（P〈0．05，P〈0．01）。（2）Snail在SACC中表达，且Snail表达与组织病理学类型及生物学行为有关，在实体型及发生神经侵犯及远处转移的病例中，Snail表达明显增加（P〈0．001，P〈0．05，P〈0．05）。（3）在SACC，E—cadherin与Snail的表达呈负相关（r=-0．496，P〈0．001）。结论snail与E—cadherin的联合检测可作为SACC恶性程度及预后的参考指标。
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| 关 键 词： | E—cadherin Snail 腺样囊性癌 |
Expression of E-cadherin and Snail in Salivary Adenoid Cystic Carcinoma and Its Significance |
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| LI Yuwang,NAN Xinrong,LINGHU Qingxi. Expression of E-cadherin and Snail in Salivary Adenoid Cystic Carcinoma and Its Significance[J]. , 2010, 48(4): 14-15,26,F0003 |
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| Authors: | LI Yuwang NAN Xinrong LINGHU Qingxi |
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| Affiliation: | LI Yuwang NAN Xinrong LINGHU Qingxi The First Affiliated Hospital of Shanxi Medical College,Taiyuan 030001,China |
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| Abstract: | ObjectiveTo study the expression of E-cadherin and Snail in salivary adenoid cystic carcinoma and its significance. Methods The expression of E-cadherin and Snail was detected by the immunohistochemical method in salivary adenoid cystic carcinoma and normal salivary gland tissue. Results(1) The expression rate of E-cadherin in salivary adenoid cystic carcinoma was lower than that in normal salivary gland tissue(P<0.05) . The E-cadherin expression was associated with different histopathological types and was... |
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| Keywords: | E-cadherin Snail |
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