丙戊酸镁缓释剂合并帕罗西汀治疗难治性抑郁症对照研究

目的：观察丙戊酸镁合并帕罗西汀治疗难治性抑郁症组的疗效及安全性。方法：将50例难治性抑郁症患者随机分为合用组（丙戊酸镁缓释剂合并帕罗西汀）25例和单用组（帕罗西汀组）25例。疗程6周。分别评定汉密尔顿抑郁量表（HAMD）和治疗中出现的症状量表（TESS）。结果：合用组HAMD量表分于治疗3周显著下降，单用组HAMD分于治疗4周显著下降，合用组有效率显著高于单用组35％（P〈0．05）。结论：丙戊酸镁缓释剂合并帕罗西汀治疗难治性抑郁疗效确切。

Accessory effect on refractory depression treated with magnesium valproate

Objective:To compare the curative effect and safety of magnesium valproate and paroxetine in treating refractory depression. Method:50 patients with refractory depression were divided into magnesium valproate group(combined used group,n=25) and paroxetine group (single used group,n=25) treated for 6 weeks.Hamilton depressive scale (HAMD) and treatment emergent symptom scale (TESS) were used to evaluate. Results:In the combined used group,HAMD decreased signifcantly at the end of the 3rd week.In the single u...