超声造影对乳腺导管内乳头状瘤的诊断价值简

目的探讨超声造：影对乳腺导管内乳头状瘤的诊断价值。方法回顾性分析2011年8月至2012年3月在北京协和医院进行乳腺手术的96例患者共96个病灶的超声造影，其中经病理证实为导管内乳头状瘤11例。超声造影增强形式分为无增强、周边增强、均匀增强、区域增强和不均匀增强，分析导管内乳头状瘤的造影特征，并与病理所见进行对照。结果11例导管内乳头状瘤经常规超声仅检出6例，病灶1．6～3．9cm；经超声造影发现另外4例，均为均匀增强，病灶0．5—1．2cm。11例导管内乳头状瘤中，均匀增强6例（54．5％），区域增强4例（36．4％），无增强1例（9．1％）。超声造影增强区组织病理学特点是扩张导管内乳头状突出物，以纤维血管为轴心，树枝样生长，提示导管内乳头状瘤；非增强区组织病理学特点主要是扩张导管和纤维组织。结论乳腺导管内乳头状瘤超声造影主要为均匀增强和区域增强，超声造影表现与组织病理学特征有关。超声造影有助于提高常规超声对导管内乳头状瘤的检出率。

Contrast-enhanced Ultrasound in the Diagnosis of Breast Intraductal Papilloma

Objective To evaluate the usefulness of contrast-enhanced ultrasound （CEUS） in the diagnosis of breast intraductal papilloma. Methods CEUS was performed after administration of sulphur hexafluoride microbubbles （SonoVue） in 96 patients scheduled for surgical tumor removal among whom 11 were histologically confirmed to be intraductal papillomas. The enhancement morphologies were classified as non-enhancement, pe- ripheral enhancement, homogeneous enhancement, regional enhancement, and heterogeneous enhancement. The histologic slides were reviewed and compared with CEUS findings. Results Of all 11 intraductal papillomas, 6 cases were detected by routine ultrasound and the sizes of lesions were 1.6 - 3.9 cm ; 4 cases were detected by CEUS with a mode of hemogeneous enhancement, and the sizes of lesions were 0. 5 - 1.2 cm. Homogeneous enhancement, regional enhancement, and non-enhancement were found in 6 cases （54. 5% ）, 4 cases （36.4%）, and 1 case （9. 1% ）, respectively. The contrast enhanced area corresponded to the intraductal papiloma, where- as the non-enhanced area corresponded to the ductal ectasis, fibrosis. Conclusion Intraductal papilloma mainly shows homogeneous or regional enhancement, and the CEUS findings correlate with histologic features.