艾灸联合五子衍宗丸治疗肾阳亏虚型弱精子症的临床观察

目的 探讨艾灸联合五子衍宗丸(下文简称“联合组”)治疗肾阳亏虚型男子弱精子症的临床疗效。方法 本研究采用随机对照研究设计,纳入符合标准的男性弱精子不育症患者70例,随机分到联合组35例(最终统计分析29例)和对照组35例(最终统计分析33例)。对照组口服五子衍宗丸,联合组在对照组基础上采用艾灸治疗,治疗周期为3个月,以精液常规分析(前向运动精子活力与精子活率)、中医临床证候量表作为观察指标,并评估其临床疗效。结果 两组的前向运动精子A级与(A+B)级]占比与精子活率较治疗前提高(P<0.05),且联合组均优于对照组(P<0.05)。联合组中医证候量表总分以及性欲淡漠、射精乏力、腰膝酸软、畏寒肢冷、夜尿增多分项评分较治疗前降低(P<0.05);且总分以及腰膝酸软、畏寒肢冷两个分项评分较对照组低(P<0.05)。联合组的总有效率为82.76%,对照组的总有效率为60.61%,且两组差异显著(P<0.05)。结论 艾灸联合五子衍宗丸治疗男性弱精子不育症明显优于单纯口服五子衍宗丸治疗,可有效改善精子活力与活率,改善各中医临床症状,具有较好的疗效。

Efficacy Observation of Wuzi-Yanzong-Wan Combined with Moxibustion on Treatment for Asthenozoospermia of Kidney-yang Deficiency Type

Objective To investigate the efficacy of Wuzi-Yanzong-Wan(WZYZW) combined with moxibustion (hereinafter referred to as "combined group") on treatment for asthenozoospermia of kidney-yang deficiency type. Methods A parallel controlled randomized study was conducted to collect 70 asthenozoospermia patients who met the inclusion criteria, which included 29 and 33 cases in the combined and control groups were statistically analyzed. The control group was given WZYZW, while the combined group was treated with moxibustion combinedwith WZYZW. With a three months treatment, the two groups adopted semen routine analysis(sperm motility and sperm viability rate) and the TCM clinical syndrome scores, and the clinical efficacy were evaluated. Results The proportion of sperm motility(Grade A and A+B) and sperm viability rate in the combined group were higher than those before treatment(P<0.05), and were better than those in the control group(P<0.05). The total score and sub-item scores(apathy of sexual desire, impotent ejaculation, soreness and weakness of waist and knees, cold shape and cold limbs, and frequent urination at night) of TCM syndrome scalein in the combined group were lower than those before treatment(P<0.05), and the total score and sub-item scores(soreness and weakness of waist and knees, cold shape and cold limbs) in the combined group were lower than those in the control group (P<0.05). The total effective rate was 82.76% in the combined group and 60.61% in the control group, and the difference was significant (P<0.05). Conclusion The Moxibustion combined with WZYZW on treatment for asthenozoospermia is significantly better than that of WZYZW, which can effectively improve sperm motility and sperm viability rate, improve the clinical symptoms of TCM, and has efficacy.