| 支链氨基酸代谢与胰岛素抵抗的研究进展 |
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| 引用本文： | 董瀚文,卢环宇,张皓琪,李天乐,畅正阳,栾百婷,骆文静,王建钰,薛冲.支链氨基酸代谢与胰岛素抵抗的研究进展[J].南华大学学报(医学版),2023(6):970-973. |
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| 作者姓名： | 董瀚文 卢环宇 张皓琪 李天乐 畅正阳 栾百婷 骆文静 王建钰 薛冲 |
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| 作者单位： | 第四军医大学 基础医学院学员四大队十五队,陕西西安 710032;第四军医大学 军队劳动与环境卫生学教研室,陕西西安 710032;第四军医大学 基础医学院学员二大队七队,陕西西安 710032;第四军医大学 基础医学院学员二大队六队,陕西西安 710032;第四军医大学 基础医学院学员三大队十二队,陕西西安 710032;第四军医大学 辐射防护医学教研室,陕西西安 710032 |
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| 基金项目： | 国家自然科学基金(82103789) |
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| 摘 要： | ]支链氨基酸是一类人体无法合成、主要靠外源性摄入的必需氨基酸。循环血液中支链氨基酸水平与胰岛素抵抗密切相关,其中哺乳动物雷帕霉素靶蛋白复合物1通路激活是支链氨基酸调控胰岛素抵抗的关键途径。本文就支链氨基酸的代谢过程及其在胰岛素抵抗形成中的作用和调控机制进行综述。
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| 关 键 词： | 支链氨基酸 胰岛素抵抗 肥胖 2型糖尿病 代谢 [ |
| 收稿时间： | 2022/11/6 0:00:00 |
| 修稿时间： | 2023/9/11 0:00:00 |
Research progress of branched-chain amino acid metabolism and insulin resistance |
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| DONG Hanwen,LU Huanyu,ZHANG Haoqi,LI Tianle,CHANG Zhengyang,LUAN Baiting,LUO Wenjing,WANG Jianyu,XUE Chong.Research progress of branched-chain amino acid metabolism and insulin resistance[J].Journal of Nanhua University(Medical Edition),2023(6):970-973. |
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| Authors: | DONG Hanwen LU Huanyu ZHANG Haoqi LI Tianle CHANG Zhengyang LUAN Baiting LUO Wenjing WANG Jianyu XUE Chong |
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| Institution: | The 15th Team of the 4th Battalion, Cadet Corps, Basic Medical College,;Department of Occupational and Environmental Health,;the 7th Team of the 2nd Battalion, Cadet Corps, Basic Medical College,;the 6th Team of the 2nd Battalion, Cadet Corps, Basic Medical College,;the 12th Team of the 3rd Battalion, Cadet Corps, Basic Medical College,;Department of Radiation Protection Medicine, Fourth Military Medical University, Xi''an 710032, shaanxi, China |
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| Abstract: | Branched-chain amino acids are a type of essential amino acids that the human body cannot synthesize thus mainly relying on exogenous intake. The level of branched-chain amino acids in the circulating blood is closely related to insulin resistance, and the activation of mammalian rapamycin target protein complex 1 pathway is a key pathway for branched-chain amino acids to regulate insulin resistance. This article reviews the metabolic process of branched-chain amino acids and their roles and regulatory mechanisms in insulin resistance. |
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| Keywords: | branched-chain amino acids insulin resistance obesity type 2 diabetes metabolism |
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