能量代谢对骨关节炎作用的研究进展

骨关节炎 （Osteoarthritis，OA） 是一种以软骨损伤为主要特征的慢性疾病，目前因其发病机制未详而尚无靶向药物。近些年诸多研究表明，线粒体功能障碍、葡萄糖代谢紊乱以及脂质代谢异常等能量代谢问题所导致的软骨细胞功能衰退加剧了OA的恶化。现有研究表明，从能量代谢途径改善软骨细胞状态，能达到缓解疼痛、减轻炎症、延缓进展与改善功能等OA治疗目的。在本综述中，我们聚焦软骨细胞能量代谢与OA软骨损伤的起因与发展的关联，旨在厘清OA的潜在治疗思路。

Research progress on role of energy metabolism in osteoarthritis

Osteoarthritis (OA) is a chronic disease characterized by cartilage damage. At present, targeted drugs are undeveloped due to unknown pathogenesis. In recent years, many studies have shown that abnormal energy metabolism such as mitochondrial dysfunction, glucose metabolism disorder and lipid metabolism abnormity in chondrocytes aggravates the deterioration of OA. The current research indicate that chondrocytes are improved from the energy metabolism pathway, it is possible to achieve the goals of OA treatment such as pain relief, inflammation reduction, delay in progression and function improvement. In this review, we focus on the association between energy metabolism of chondrocytes and the cause and development of cartilage damage in OA, aiming to clarify the potential therapeutic strategies for OA.