儿童造血干细胞移植后皮肤GVHD评估与预防最佳证据总结

目的 总结儿童造血干细胞移植后皮肤移植物抗宿主病护理最佳证据，为临床护理提供指引。方法 计算机检索BMJ Best Practice、UpToDate、JBI循证卫生保健中心数据库、中国抗癌协会护理专业委员会、PubMed、中国知网、万方数据等数据库，检索时限为2000年1月1日至2023年5月31日。结果 共纳入文献17篇（临床决策3篇，指南7篇，系统评价1篇，专家共识4篇，证据总结2篇），总结出皮肤评估、皮肤防护、皮肤不良反应的处理、用药指导、随访与筛查5个方面24条最佳证据。结论 总结的儿童造血干细胞移植后皮肤移植物抗宿主病护理最佳证据，可作为指引用于临床护理。

Summary of best evidence for assessment and prevention of cutaneous graft-versus-host disease after hematopoietic stem cell transplantation in children

Objective To summarize the best evidence for care of cutaneous graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation in children, and to provide guidance for clinical care. Methods BMJ Best Practice, UpToDate, the Joanna Briggs Institute Evidence-Based Practice Database, Nursing Professional Committee of Chinese Anti-Cancer Association, PubMed, CNKI, WanFang data and other databases were searched from January 1, 2000 to May 31, 2023. Results A total of 17 publications were eligible (3 clinical decision recommendations statements, 7 guidelines, 1 systematic review, 4 expert consensus reports and 2 evidence summaries), and 24 pieces of best evidence were summarized in 5 aspects: skin assessment, skin protection, management of adverse skin reactions, medication guidance, follow-up and screening. Conclusion The best evidence for the care of cutaneous GVHD after hematopoietic stem cell transplantation in children can be used as a guidance for clinical care.