Spray freeze drying for dry powder inhalation of nanoparticles |
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| Institution: | 1. Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany;2. Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt;3. Laboratory of Pharmaceutical Engineering, University of Franche-Comté, Besançon, France;1. Institute of Process and Particle Engineering, Graz University of Technology, 8010 Graz, Austria;2. Research Center Pharmaceutical Engineering, Graz, 8010 Graz, Austria;1. Department of Medical Microbiology, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands;2. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands;1. Bengal College of Pharmaceutical Sciences and Research, Biplabi Rash Bihari BasuSarani, Bidhan Nagar, Durgapur-713212, West Bengal, India;2. N R. Vekaria Institute of Pharmacy, C. L. College Campus,Bilkha Road, Junagadh–362001, Gujarat, India;3. Department of Chemistry & Biochemistry, Laurentian University,935 Ramsey Lake Rd. Sudbury, ON, P3E 2C6, Canada;1. Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151 Malianwa North Road, Haidian District, Beijing, 100193, PR China;2. Medical College, Anhui University of Science & Technology, Huainan, Anhui, 232001, PR China |
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| Abstract: | Formulating nanoparticles for delivery to the deep lung is complex and many techniques fail in terms of nanoparticle stability. Spray freeze drying (SFD) is suggested here for the production of inhalable nanocomposite microcarriers (NCM). Different nanostructures were prepared and characterized including polymeric and lipid nanoparticles. Nanoparticle suspensions were co-sprayed with a suitable cryoprotectant into a cooled, stainless steel spray tower, followed by freeze drying to form a dry powder while equivalent compositions were spray dried (SD) as controls. SFD-NCM possess larger specific surface areas (67–77 m2/g) and lower densities (0.02 g/cm3) than their corresponding SD-NCM. With the exception of NCM of lipid based nanocarriers, SFD produced NCM with a mass median aerodynamic diameter (MMAD) of 3.0 ± 0.5 μm and fine particle fraction (FPF ? 5.2 μm) of 45 ± 1.6% with aerodynamic performances similar to SD-NCM. However, SFD was superior to SD in terms of maintaining the particle size of all the investigated polymeric and lipid nanocarriers following reconstitution (Sf/Si ratio for SFD ≈ 1 versus >1.5 for SD). The SFD into cooled air proved to be an efficient technique to prepare NCM for pulmonary delivery while maintaining the stability of the nanoparticles. |
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| Keywords: | Spray freeze drying Spray drying Pulmonary Nanoparticles Dry powder Inhalation Nanocomposite microcarriers |
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