| 京玉清肝胶囊对实验性肝损伤的保护作用 |
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| 引用本文： | 黄芳,刘云. 京玉清肝胶囊对实验性肝损伤的保护作用[J]. 中国现代中药, 2006, 8(4): 10-13,16 |
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| 作者姓名： | 黄芳 刘云 |
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| 作者单位： | 1. 中国药科大学,江苏,南京,210009
2. 北京万赛生物医药技术发展有限公司,北京,100089 |
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| 摘 要： | 目的：研究京玉清肝胶囊对小鼠、大鼠实验性肝损伤的保护作用。方法：采用四氯化碳（CCl4）或D-半乳糖胺（D—Gain）所致肝损伤模型为研究对象，观察京玉清肝胶囊对实验性肝损伤的保护作用。结果：京玉清肝胶囊能显著降低CCl4和JD—GaIN所引起急性肝损伤小鼠血清ALT、AST含量；能明显抑制CCl4所引起的慢性肝损伤大鼠血清ALT、AST及肝脏中羟脯氨酸的含量。结论：京玉清肝胶囊对CCl4或JD～GalN引起的小鼠急性肝损伤、CCl4起的大鼠肝损伤有保护作用。
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| 关 键 词： | 京玉清肝胶囊 实验性肝损伤 四氯化碳 D-半乳糖胺 |
| 收稿时间： | 2006-01-09 |
| 修稿时间： | 2006-01-09 |
The Effect of Jingyuqinggan Capsule on Experimental Liver Injury |
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| Huang Fang and Liu Yun. The Effect of Jingyuqinggan Capsule on Experimental Liver Injury[J]. Modern Chinese Medicine, 2006, 8(4): 10-13,16 |
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| Authors: | Huang Fang and Liu Yun |
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| Affiliation: | China Pharmaceutical University, Nanjing Jiangsu 210009, China;Beijing Wansai Biomedical Science Co., Ltd, Beijing 100089, China |
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| Abstract: | Objective:To study the effect of Jinyuqinggan Capsule on experimental liver injury in mice and rats.Methods:Taking liver-injured mice model induced by CCl_(4) and D-galactamine(D-GalN) as the subject,to observe the related indexes.Results:Jingyuqinggan Capsule could suppress the elevation of alanine aminotransferase(ALT),aspartate aminotransferase(AST) in serum of liver injury mice induced by CCl_(4)and D-GalN,and decrease the ALT,AST in rat serum and hydroxyproline in hepatic tissue.Conclusion:It is suggest that Jinyuqinggan Capsule may have the protection effect on experimental live injury in mice and rats. |
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| Keywords: | Jingyuqinggan Capsule Experimental liver injury carbon tetrachloride D -galactamine. |
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