舍曲林和伐地那非治疗合并勃起功能障碍的早泄患者的临床观察

目的:评价舍曲林和伐地那非治疗合并勃起功能障碍(ED)的早泄患者的临床疗效和安全性。方法:60例诊断为合并ED的早泄患者随机分为舍曲林组和伐地那非组,每组30例。舍曲林组每天服用舍曲林50 mg,疗程2个月。伐地那非组每次性生活前服用伐地那非10~20 mg,疗程2个月。以治疗前后IIEF-5评分的改变来评价ED治疗效果,以治疗前后阴道内射精潜伏期(IELT)的变化来评价早泄治疗效果。结果:伐地那非组勃起功能改善24例,有效率为80%;而舍曲林组仅8例勃起功能改善,有效率为27%,两者差异有显著性(P<0.05)。伐地那非组早泄改善20例,有效率为67%;而舍曲林组早泄改善12例,有效率为40%,两者差异有显著性(P<0.05)。两组患者中,勃起功能改善者的早泄治疗的有效率均显著高于勃起功能无改善者。两组的不良反应均为轻度,无停药者。结论:对合并ED的早泄患者,改善患者的勃起功能是关键。

A Clinical Study of Sertralin and Vardenafil in the Treatment of Premature Ejaculation Complicated by Erectile Dysfunction

Objective: To evaluate the efficacy and safety of sertralin and vardenafil in the treatment of patients with concomitant erectile dysfunction(ED) and premature ejaculation(PE).Methods: Sixty patients with concomitant ED and PE received at our clinic of androloy were randomly divided into a vardenafil group and a sertralin group.The vardenafil group received flexible doses of vardenafil from 10 mg to 20 mg and the sertralin group 50 mg daily,both for 2 months.The differences in IIEF-5 before and after the treatment were recorded and compared,and the results of ED treatment evaluated.Intravaginal ejaculatory latency time(IELT) was recorded to evaluate the outcome of PE treatment.Results: In the vardenafil group,24 patients had their ED improved and the efficacy rate was 80%,as compared with 27% in the sertralin group.There was significant difference between the two groups(P<0.05).Twenty patients had their PE improved in vardenafil group,with an efficacy rate of 67% as compared with 40% in the sertralin group.The difference was significant between the two groups(P<0.05).In both of the two groups,a significantly higher rate of PE improvement was found in patients with improved ED than in those without.Only mild side effects were recorded,and none withdrew from the treatment.Conclusion: To patients with concomitant ED and PE,the key to the treatment is to improve their erectile function,and for this purpose,vardenafil works better than sertralin.