Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury |
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| Authors: | Yuzhen Dong Libin Yang Lin Yang Hongxing Zhao Chao Zhang Dapeng Wu |
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| Institution: | Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China |
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| Abstract: | Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury. |
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| Keywords: | nerve regeneration spinal cord injury cell transplantation neurotrophin-3 bone marrowmesenchymal stem cells cell apoptosis spinal cord anterior horn motor neurons neural regeneration |
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