免疫吸附技术的临床应用体会

目的　为了评价蛋白A免疫吸附和低密度脂蛋白免疫吸附对免疫球蛋白(主要为IgG)和低密度脂蛋白(LDL)的吸附作用及临床效果。方法　使用瑞典Excorim公司的Citem10吸附-洗脱环路系统,对7例自身免疫性疾病和3例高脂血症患者进行了16例次免疫吸附治疗,并将治疗前后血浆免疫球蛋白或血脂进行对比分析。结果　吸附治疗后血浆IgG、IgA、IgM均明显低于吸附前的水平(P<0.001),LDL、Lp(a)、甘油三脂、胆固醇分别下降了70.9%、53.3%、19.7%、53.0%,而高密度脂蛋白(HDL)较吸附前增高51.3%。结论　蛋白A免疫吸附和低密度脂蛋白免疫吸附可以选择性地、有效地清除血浆IgG及LDL,缓解临床症状,且未见明显副作用。

The Experiences in Clinical Application of Immunoadsorption

Objective To assess the effects on protein A immunoadsorption and LDL-immunoapheresis. Methods Seven patients with autoimmune disease and 3 hepercholesterolemic patients underwent a total of 16 immunoadsorption procedures with Citem 10 System. Results Comparing with the profile of pre-and post-immunoadsorption,the plasma IgG,IgA,IgM levels were decreased significantly(P<0.001), and plasma LDL,Lp(a), triglyceride and cholesterol levels were lowered by 70.9%,53.3%,19.7%,53.0%,respectively, but HDL level was increased by 51.3%. Conclusion Protein A immunoadsorption and LDL-immuno apheresis appear to be a selective, effective and specific approach for lowering IgG or LDL without significant side effects.