创面用变革对深Ⅱ°烧伤创面愈合时间的影响

目的通过对深Ⅱ°烧伤创面愈合时间的分阶段对比分析，了解创面愈合观念及创面用药变革对创面愈合速度的影响。方法1982年1月～1999年12月对1563例小面积深Ⅱ°烧伤患者(总面积≤10%)，按创面补锌及生长因子和胶原酶应用等治疗措施采用时间不同，分为时间阶段，对比观察创面愈合速度变化。结果1982年1月～1990年12月，未使用特殊创面外用药物，创面愈合时间为(23.8±3.5)天；1991年～1996年，采用银锌霜创面补锌，创面愈合时间为(20.6±3.2)天；1997年～1999年，将脱痂药物(胶原酶)及生长因子与银锌霜联合使用，使创面愈合时间缩短为(16.2±2.8)天。结论创面愈合观念及创面用药变革促进了深Ⅱ°创面愈合。

EFFECT OF IMPROVED TOPICAL AGENTS ON HEALING TIME OF DEEP SECOND-DEGREE BURN WOUND

OBJECTIVE: With the recognization of the mechanism of wound healing, some topical agents are created and applied in trauma to improve the healing rate of wounds. The main purpose of this study is to investigate the effect of some topical agents on the healing rate of deep second-degree burn wounds. METHODS: One thousand five hundred and sixty-three patients with deep second-degree burn wounds(total burn surface area < or = 10%) were involved in this study from January 1982 to December 1999. According to the application time of different treating measures including supplement of Zn, application of growth factors and collagenase, the patients were divided into 3 groups, wound healing rates were compared. RESULTS: Before 1991, none of special topical agents were used, and the healing time of deep second-degree burn wounds was(23.8 +/- 3.5) days. From 1991 to 1996, with the topical application of SD-Ag-Zn, which can provide Zn for cells taking part in wound healing, the healing time of deep second-degree burn wounds was (20.6 +/- 3.2) days, earlier than no special topical agents (P < 0.05). From 1997 to 1999, growth factors such as basic fibroblast growth factor(bFGF) and epithelial growth factor (EGF) and collagenases were applied in wound treatment combining with SD-Ag-Zn, wound healing time was (16.2 +/- 2.8) days, earlier than no special topical agents (P < 0.01) and simple SD-Ag-Zn application (P < 0.05). CONCLUSION: It indicates that the improvement of topical agents can accelerate wound healing speed.