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某院外科围手术期抗菌药预防性应用的干预性研究
引用本文:杨红英,贾孟良,陈振德,曾文莉,林山鹰.某院外科围手术期抗菌药预防性应用的干预性研究[J].中国药师,2009,12(8):1111-1113.
作者姓名:杨红英  贾孟良  陈振德  曾文莉  林山鹰
作者单位:深圳市人民医院暨南大学第二临床医学院,广东深圳518020
基金项目:广东省医院药学研究基金 
摘    要:目的:通过某院外科围手术期抗菌药预防性应用的干预性研究,为临床抗菌药的应用和管理提供依据。方法:分别随机抽取某院手术科室2008年7月和11月出院病人的手术病历各200份,调查分析干预前后围手术期预防性应用抗菌药情况。结果:干预后术前〉2h应用抗菌药的比例由11%减少到4.5%(P〈0.05),术前0.5~2h应用抗菌药比例由4.5%提高到38%(P〈0.05),术后开始应用抗菌药比例由84.5%降到57.5%(P〈0.05);抗菌药平均应用时间由7.3d减少到5.2d。干预后围手术期抗菌药预防性应用的合理性明显提高,伤口感染率及医院感染率无明显改变。结论:本研究所采取的抗菌药预防性应用的干预措施具有可行性和有效性,对促进安全、合理地使用抗菌药起到了积极的促进作用。

关 键 词:围手术期  抗菌药  干预性研究

Intervention Study of Perioperative Use of Prophylactic Antibiotics
Yang Hongying,Jia Mengliang,Chen Zhende,Zeng Wenli,Lin Shanying.Intervention Study of Perioperative Use of Prophylactic Antibiotics[J].China Pharmacist,2009,12(8):1111-1113.
Authors:Yang Hongying  Jia Mengliang  Chen Zhende  Zeng Wenli  Lin Shanying
Institution:( Shenzhen People's Hospital, Second Chnical Medicine College of Jinan University, Guangdong Shenzhen 518020, China)
Abstract:Objective : To provide the evidence for the correct application and administration of antibiotics by intervention study of perioperative use of prophylactic antibiotics in a hospital. Method : Four hundreds surgery patients were sampled randomly from July and Nov. 2008 in a hospital and the perioperative use of prophylactic antibiotics was investigated. Result : The application ratios of antibacterials 〉 2h before surgery significantly decreased from 11% to 4.5% , 0.5 - 2h before surgery significantly increased from 4. 5% to 38% , after operation significantly decreased from 84.5% to 57.5% respectivelyafter the intervention . The average duration of antibiotic use decreased from 7.3d to 5.2d. Rationality was obviously enhanced for properapplication of antibiotics in perioperative period by the intervention. The rate of wound infection and nosocomial infection was not differenct. Conclusion: The intervened method of antibiotics is feasible and effective. It can promote the correct application of antibiotics.
Keywords:Perioperative period  Antibiotic  Intervention study
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